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Image Search Results
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effect of L. plantarum supplementation on cognitive impairments in APP/PS1 mice. APP/PS1 mice were treated with memantine, L. plantarum , or memantine+ L. plantarum . The preferential index after training 1 hour ( A ) in the phase of novel object test, latency in the learning phase ( B ), latency ( C ), time spent in target quadrant ( D ) and number of crossing plate ( E ) in the testing phase of Morris water maze test, successful avoidance times in testing phase ( F ) of shuttle box test. ** P <0.01, *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, ### P <0.001, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP= L. plantarum .
Article Snippet: Six-month-old
Techniques:
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effect of L. plantarum supplementation on long-term potentiation (LTP) decline in APP/PS1 mice. The population spike (PS) amplitudes and LTP induction were recorded in WT and APP/PS1 mice ( A ). Summary of average PS amplitude (31-90 minutes) from all experiments shown in A ( B ). *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, ### P <0.001, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. W=wild type; Mem=memantine; LP= L. plantarum .
Article Snippet: Six-month-old
Techniques:
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effect of L. plantarum supplementation on Αβ deposition in APP/PS1 mice. Representative immunofluorescence staining images showing Αβ plaques (green and indicated by red arrows) in the hippocampus of WT and APP/PS1 mice ( A ). Quantitative analysis of Αβ plaques ( B ), Aβ 1-40 ( C ) and Aβ 1-42 ( D ) in the hippocampus was used by Image Pro Plus 6.0 software and AlphaLISA assay. *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP= L. plantarum .
Article Snippet: Six-month-old
Techniques: Immunofluorescence, Staining, Software
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effects of L. plantarum supplementation on hippocampal neuron and plasticity in APP/PS1 mice. Representative images of Nissl staining images (upper panel) and dendritic spines (lower panel) under microscopy in the hippocampus of WT and APP/PS1 mice ( A ). Quantification of and Nissl bodies ( B ) and mean dendritic spine density ( C ). The expression of hippocampal synaptophysin ( D ) and PSD95 protein ( E ). *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP= L. plantarum .
Article Snippet: Six-month-old
Techniques: Staining, Microscopy, Expressing
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effects of L. plantarum supplementation on TMAO synthesis in APP/PS1 mice. The concentration of TMA ( A ), TMAO ( B ) in plasma, and FMO3 ( C ) in the liver. Liver FMO activity, assessed as described in Materials and Methods ( D ). *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, ### P <0.001, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP= L. plantarum .
Article Snippet: Six-month-old
Techniques: Concentration Assay, Clinical Proteomics, Activity Assay
Journal: Aging (Albany NY)
Article Title: Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
doi: 10.18632/aging.102645
Figure Lengend Snippet: Effects of L. plantarum supplementation on the levels of clusterin in plasma and inflammatory status in the hippocampus of WT and APP/PS1 mice. The concentration of plasma clusterin ( A ). Heat map of cytokine concentrations ( z -score) in the hippocampus ( B ). * represents a difference between WT and APP/PS1 mice, # represents a difference between APP/PS1 mice and treated APP/PS. The concentration of interleukin (IL)-2 ( C ), IL-17 ( D ) and tumor necrosis factor α (TNFα) ( E ) in the hippocampus. *** P <0.001, versus the WT mice, by unpaired Student's t -tests. # P <0.05, ## P <0.01, ### P <0.001, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP= L. plantarum . IL=interleukin; IP=interferon-induced protein; GM-CSF=granulocyte-macrophage colony-stimulating factor; IFNγ=interferon-γ; TNF-α=tumor necrosis factor α; MCP-1=monocyte chemotactic protein-1; RANTES=regulated upon activation normal T cell expressed and secreted factor; MIP-1β=macrophage inflammatory protein-1β; G-CSF=granulocyte colony-stimulating factor.
Article Snippet: Six-month-old
Techniques: Clinical Proteomics, Concentration Assay, Activation Assay